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phospho camp response element  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc phospho camp response element
    Phospho Camp Response Element, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho+camp+response+element/pm41898208-50-29-44?v=Cell+Signaling+Technology+Inc
    Average 86 stars, based on 1 article reviews
    phospho camp response element - by Bioz Stars, 2026-07
    86/100 stars

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    Proposed mechanism underlying the neuroprotective effects of OXT against CORT-induced dopamine dysfunction in SH-SY5Y cells. OXT binds to its receptor, resulting in augmented stimulation of cAMP, which serves as an activator of PKA. Subsequently, PKA phosphorylates TH at Ser40 and CREB at Ser133. Phosphorylated CREB can bind to downstream coactivators to orchestrate the transcriptional activity of its target, including the TH gene. This regulatory process contributes to the protective effects of OXT against CORT-induced toxicity, thereby conferring neuroprotection. (Created with BioRender.com/Mahidol University)

    Journal: Neurochemical Research

    Article Title: Oxytocin Protects Against Corticosterone-Induced DA Dysfunction: An Involvement of the PKA/CREB Pathway

    doi: 10.1007/s11064-024-04294-7

    Figure Lengend Snippet: Proposed mechanism underlying the neuroprotective effects of OXT against CORT-induced dopamine dysfunction in SH-SY5Y cells. OXT binds to its receptor, resulting in augmented stimulation of cAMP, which serves as an activator of PKA. Subsequently, PKA phosphorylates TH at Ser40 and CREB at Ser133. Phosphorylated CREB can bind to downstream coactivators to orchestrate the transcriptional activity of its target, including the TH gene. This regulatory process contributes to the protective effects of OXT against CORT-induced toxicity, thereby conferring neuroprotection. (Created with BioRender.com/Mahidol University)

    Article Snippet: Polyclonal rabbit anti-phospho-tyrosine hydroxylase (Ser40) antibody (pTH, Cat. No. 2791 S), monoclonal rabbit anti-phospho-cAMP-response-element-binding-protein (Ser133) antibody (pCREB; Cat. No. 9198 S), and polyclonal rabbit anti-catalytic-protein kinase A-α subunit antibody (PKAc-α; (Cat. No. 4782 S) were purchased from Cell Signaling Technology (Beverly, MA, USA).

    Techniques: Activity Assay